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Performance of Amperometric Platinized‐Nafion Based Gas Phase Sensor for Determining Nitric Oxide (NO) Levels in Exhaled Human Nasal Breath
Author(s) -
Zajda Joanna,
Schmidt Nicholas J.,
Zheng Zheng,
Wang Xuewei,
Meyerhoff Mark E.
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800140
Subject(s) - amperometry , exhaled nitric oxide , carbon monoxide , chemistry , exhalation , chemiluminescence , nitric oxide , exhaled air , chromatography , materials science , electrode , medicine , anesthesia , catalysis , lung , biochemistry , organic chemistry , lung function , toxicology , electrochemistry , biology
Nitric oxide (NO) levels in exhaled breath are a non‐invasive marker that can be used to diagnose various respiratory diseases and monitor a patient's response to given therapies. A portable and inexpensive device that can enable selective NO concentration measurements in exhaled breath samples is needed. Herein, the performance of an amperometric Pt‐Nafion‐based gas phase sensor for detection of NO in exhaled human nasal breath is examined. Enhanced selectivity over carbon monoxide and ammonia is achieved via an in‐line zinc oxide‐based filter. Exhaled nasal NO levels measured in 21 human samples with the sensor are shown to correlate well with those obtained using a chemiluminescence reference method (R 2 =0.9836).