Premium
Ordered Mesoporous Carbon/Poly (2‐Hydroxyethyl Methacrylate/Ag Nanoparticle Composite Modified Glassy Carbon Electrode; an Amplified Sensor for Simultaneous Determination of Acetaminophen and Domperidone
Author(s) -
Khoshsafar Hamid,
Rofouei Mohammad Kazem,
Bagheri Hasan,
Kalbasi Roozbeh Javad
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800068
Subject(s) - domperidone , materials science , differential pulse voltammetry , nuclear chemistry , dielectric spectroscopy , methacrylate , nanocomposite , electrochemical gas sensor , fourier transform infrared spectroscopy , cyclic voltammetry , electrode , electrochemistry , chemistry , chemical engineering , copolymer , nanotechnology , composite material , polymer , neuroscience , dopamine , engineering , biology
Abstract In this study, we describe a modification of a glassy carbon electrode with an ordered mesoporous carbon (OMC)/poly (2‐hydroxyethyl methacrylate) (PHEMA)/Ag nanoparticle composite (GCE/AgNPs‐PHEMA‐CMK‐1) done for the first time and the application of a proposed sensor for the simultaneous determination of acetaminophen (AC) and domperidone (DO). The transmission electron microscopy (TEM), fourier‐transform infrared spectroscopy (FT‐IR), electrochemical impedance spectroscopy (EIS), UV‐vis spectroscopy, and X‐ray powder diffraction (XRD) methods were used for the analysis of the synthesized nanocomposite. The GCE/AgNPs‐PHEMA‐CMK‐1 showed good catalytic activity for the electro‐oxidation of acetaminophen and domperidone in the buffer solution. The pH investigation showed that acetaminophen and domperidone electro‐oxidation is relative to the pH value of the solution. The maximum oxidation process occurred at pH=7.0 and pH=8.0 for acetaminophen and domperidone, respectively, on the surface of the GCE/AgNPs‐PHEMA‐CMK‐1. The GCE/AgNPs‐PHEMA‐CMK‐1 showed a linear range between 0.015–7.5 μM and 0.03–10.8 μM for acetaminophen and domperidone, respectively. The GCE/AgNPs‐PHEMA‐CMK‐1 showed detection limits of 0.005 and 0.01 μM for acetaminophen and domperidone, respectively, by the differential pulse voltammetry (DPV) method. Finally, the GCE/AgNPs‐PHEMA‐CMK‐1 was suggested as a highly powerful tool for the analysis of acetaminophen and domperidone in real samples.