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Electrocatalytic Oxidation and Flow Injection Analysis of Isoniazid Drug Using an Unmodified Screen Printed Carbon Electrode in Neutral pH
Author(s) -
Gopinathan Manavalan,
Thiyagarajan Natarajan,
Thiruppathi Murugan,
Zen JyhMyng
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800021
Subject(s) - electrode , overpotential , detection limit , materials science , flow injection analysis , x ray photoelectron spectroscopy , sensitivity (control systems) , linear range , electrolyte , analytical chemistry (journal) , carbon fibers , chemistry , chemical engineering , chromatography , electrochemistry , electronic engineering , composite material , composite number , engineering
In this work we report electrocatalytic oxidation and flow injection analysis of tuberculostatic drug isoniazid (INZ) based on a disposable and unmodified screen printed carbon electrode (SPCE). Instead of using chemically modified electrode to increase the sensitivity at low overpotential, the same purpose can be achieved simply by preanodization of a bare SPCE in a suitable electrolyte medium. Surface characterization of the as‐preanodized electrode by X‐ray photoelectron spectroscopy and Raman spectroscopy indicate that both oxygen functionalities and edge/defect sites effectively assist the INZ oxidation. Flow injection analysis extends its applicability with a wide linear range up to 1 mM and an enhanced sensitivity of 100 nA μM −1 with a low detection limit of 2.7 nM (S/N=3). These good analytical features accomplished with disposable and economical devices could make possible the implementation of this methodology for INZ on‐line monitoring in pharmaceuticals.