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Sensitive and Selective Electrochemical Determination of L‐Cysteine Based on Cerium Oxide Nanofibers Modified Screen Printed Carbon Electrode
Author(s) -
Cao Fei,
Dong Qiuchen,
Li Caolong,
Kwak Dongwook,
Huang Yikun,
Song Donghui,
Lei Yu
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800008
Subject(s) - amperometry , electrode , detection limit , materials science , electrochemistry , scanning electron microscope , electrochemical gas sensor , cyclic voltammetry , selectivity , cerium , analytical chemistry (journal) , inorganic chemistry , chemistry , chromatography , catalysis , organic chemistry , composite material , metallurgy
A novel L‐cysteine (CysH) electrochemical sensor based on CeO 2 nanofibers (NFs) modified screen printed carbon electrodes (SPCEs) was developed. The morphology and the structure of the as‐prepared CeO 2 NFs were first characterized using scanning electron microscopy (SEM) and X‐ray diffraction pattern (XRD), respectively. The electrochemical and electrocatalytic performances of the CeO 2 NFs modified SPCEs were then evaluated using cyclic voltammetry and amperometry. Experimental results showed that the CeO 2 NFs modified SPCEs possess excellent electrocatalytic activity toward the detection of CysH. Specifically, the developed electrochemical sensor demonstrated a high sensitivity of 120 μA mM −1 cm −2 , a low detection limit of 20 nM (signal to noise ratio of 3) and a wide linear range up to 200 μM for the determination of CysH, which are among the best values reported in literature. In addition, good selectivity and outstanding intra‐ and inter‐electrode reproducibility have also been observed. Furthermore, the developed CysH sensor was applied to detect CysH spiked into human serum samples with remarkable accuracy. All these features indicate that CeO 2 NFs hold great promise in the development of high performance electrochemical sensor for CysH.