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Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid
Author(s) -
Chatard Charles,
Meiller Anne,
Marinesco Stéphane
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201700836
Subject(s) - microelectrode , multielectrode array , biosensor , neuroscience , interstitial fluid , neurochemistry , glutamate receptor , brain tissue , neurotransmitter , chemistry , biophysics , nanotechnology , biochemistry , electrode , biology , materials science , neurology , central nervous system , endocrinology , receptor
Chemical analyses of brain interstitial fluid can reveal important information about local brain metabolism and neurochemistry, and can enhance our understanding of how neuronal networks respond to physiological or pathological stimuli. Among brain monitoring methods currently available, microelectrode biosensors provide real‐time analyses with high temporal resolution and minimal perturbation to living tissue by using oxidase enzymes for biological recognition. Two types of microelectrodes are used: cylindrically shaped wire electrodes provide the smallest implantable devices to date, and microfabricated multi‐electrode needles can monitor several molecules simultaneously. They have already contributed significantly to our understanding of brain energy metabolism with glucose and lactate detection, and to neurotransmitter systems with glutamate, D‐serine, acetylcholine, and purine detection. They have the potential to undergo further technological developments in future studies.