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Nano‐species Release System Activated by Enzyme‐based XOR Logic Gate
Author(s) -
Filipov Yaroslav,
Gamella Maria,
Katz Evgeny
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201700742
Subject(s) - xor gate , electrode , fluorescence , radical , materials science , yield (engineering) , chemistry , immobilized enzyme , enzyme , logic gate , nanotechnology , combinatorial chemistry , chemical engineering , organic chemistry , computer science , metallurgy , physics , algorithm , quantum mechanics , engineering
An enzyme‐based XOR logic gate was realized at interface of an alginate‐modified electrode. The biocatalytic production of H 2 O 2 inside the alginate film was controlled by logically processed input signals. The in situ generated H 2 O 2 was decomposed to yield free radicals in a Fenton‐type reaction catalyzed by iron cations, which were present in the alginate film as cross‐linkers stabilizing the hydrogel. The produced free radicals (•OH, •OOH) resulted in decomposition/dissolution of the alginate film removing it from the electrode surface and stimulating release process of magnetic nanoparticles (MNPs) functionalized with a fluorescent dye and entrapped in the alginate film. The release of the MNPs was analyzed by following fluorescence appearing in the solution. The release process followed the logic features of the XOR gate. The present system is the first realization of the enzyme‐based XOR gate functionally integrated with the downstream actuation process in the form of the signal‐stimulated release.