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A Voltammetric Sensory System for Recognition of Propranolol Enantiomers Based on Glassy Carbon Electrodes Modified by Polyarylenephthalide Composites of Melamine and Cyanuric Acid
Author(s) -
Zilberg Rufina A.,
Sidelnikov Artem V.,
Maistrenko Valery N.,
Yarkaeva Yulia A.,
Khamitov Edward M.,
Kornilov Viktor M.,
Maksutova Elza I.
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201700404
Subject(s) - cyanuric acid , melamine , enantiomer , cyanuric chloride , electrode , materials science , carbon fibers , glassy carbon , electrochemistry , chemistry , composite material , cyclic voltammetry , organic chemistry , polymer chemistry , composite number
An enantioselective voltammetric sensory system based on glassy carbon electrodes modified by polyarylenephthalide composites of melamine and cyanuric acid using chemometric method principal component analysis for the recognition of propranolol enantiomers was developed. It is shown that glassy carbon electrodes modified by polyarylenephthalide composites of melamine and cyanuric acid exhibit the properties of enantioselective sensors. The molecular dynamics simulations of the interaction processes of propranolol enantiomers with polyarylenephthalide composites of melamine and cyanuric acid show that the differences between the voltammograms of propranolol enantiomers on such electrodes are due to differences in the energy of hydrogen bonds formation between enantiomeric molecules and supramolecules of melamine and cyanuric acid. This is reflected not only in the characteristics and shape of the voltammograms, but also in the sensitivity of the electrodes, with respect to the propranolol enantiomers. The possibilities of the sensory system for express recognition of R‐ and S‐propranolol are considered. The recognition of these enantiomers by the registered voltammograms on two glassy carbon electrodes modified by polyarylenephthalide composites of melamine and cyanuric acid allows to increase significantly the percentage of correctly recognised samples in comparison with the registration of voltammograms on only one electrode.