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Fabrication of Electrochemical Sensor Based on Layered Double Hydroxide/Polypyrrole/Carbon Paste for Determination of an Alpha‐adrenergic Blocking Agent Terazosin
Author(s) -
Hassanein A.,
Salahuddin N.,
Matsuda A.,
Hattori T.,
Elfiky M.
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201700321
Subject(s) - polypyrrole , carbon paste electrode , electrochemistry , hydroxide , materials science , polymerization , electrode , nanocomposite , pyrrole , chemical engineering , electrochemical gas sensor , intercalation (chemistry) , chemistry , cyclic voltammetry , inorganic chemistry , polymer , organic chemistry , nanotechnology , engineering
New insights into the design of highly sensitive, carbon‐based electrochemical sensors are presented in this work. This was achieved by exploring the interesting properties of conductive (Mg/Al) layered double hydroxide‐dodecyl sulphate/polypyrrole nanocomposites which were synthesized by in‐situ polymerization of pyrrole during the assembly of (Mg/Al) layered double hydroxide, and by employing the anionic surfactant dodecyl sulphate as a modifier. Changes in morphology and surface area of the nanocomposites occured as a result of change in pyrrole percentage. Under optimal conditions, the modified carbon paste electrode successfully achieved detection limits of 0.057 and 0.134 nmol L −1 of Terazosin hydrochloride in pharmaceutical formulation and spiked human serum fluid, respectively. Moreover, the sensors are highly stable, reusable and free of interference by other commonly present excipients in drug formulations.