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Determination of Manganese in Whole Blood by Cathodic Stripping Voltammetry with Indium Tin Oxide
Author(s) -
Rusinek Cory A.,
Kang Wenjing,
Nahan Keaton,
Hawkins Megan,
Quartermaine Cooper,
Stastny Angela,
Bange Adam,
Papautsky Ian,
Heineman William R.
Publication year - 2017
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201700137
Subject(s) - cathodic stripping voltammetry , chemistry , indium , manganese , indium tin oxide , oxide , inductively coupled plasma mass spectrometry , atomic absorption spectroscopy , analytical chemistry (journal) , voltammetry , inorganic chemistry , materials science , electrode , mass spectrometry , electrochemistry , chromatography , physics , organic chemistry , quantum mechanics
Manganese (Mn) is a required trace metal in the body. In recent years however, it has garnered significant attention as a developmental neurotoxin in children with chronic exposure. It has been linked to complications such as memory loss with negatively associated IQ scores, attention deficit hyperactivity disorder (ADHD), and in extreme cases, the development of a Parkinson's disease analogue‐manganism. Cathodic stripping voltammetry (CSV) has proven to be a suitable method for electroanalytical determination of Mn. We have established Mn CSV using indium tin oxide (ITO) as the working electrode for the determination of Mn in bovine whole blood after an acid digestion. Reliable, accurate, and precise results were obtained, as only 9 % variation in the digested blood was observed. The CSV results were compared with graphite‐furnace atomic absorption spectroscopy (GF‐AAS) and inductively coupled plasma‐ mass spectrometry (ICP‐MS) and favorable agreement across the methods was observed. Due to ITO's excellent positive potential window and stability under harsh environments, this method could be applied to other oxide‐forming transition metals detectable by CSV.