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Application of a Nanosensor Based on MWCNT‐Sodium Dodecyl Sulphate Modified Electrode for the Analysis of a Novel Drug, Alpha‐Hydrazinonitroalkene in Human Blood Serum
Author(s) -
D'Souza Ozma J,
Mascarenhas Ronald J,
Satpati Ashis K,
Mane Vaijinath,
Mekhalif Zineb
Publication year - 2017
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201700114
Subject(s) - detection limit , ascorbic acid , nanosensor , electrode , electrochemical gas sensor , electrochemistry , analyte , carbon nanotube , materials science , dielectric spectroscopy , blood serum , nuclear chemistry , analytical chemistry (journal) , chemistry , chromatography , nanotechnology , food science , endocrinology , medicine
The sensitivity enhancing properties of sodium dodecyl sulphate (SDS) and multi‐walled carbon nanotubes (MWCNTs) were associated to construct a nanosensor based on carbon paste electrode (CPE) by adopting drop cast method. The drop cast method makes use of minimum modifier and the entire modified surface of the sensor is available for the analyte. Surface characterization of the electrodes was carried out using FE‐SEM and EDX. EIS was used for the electrochemical characterization. We report for the first time the electrochemical analysis based on the oxidation of the ‐OH group of a novel drug, alpha‐hydrazinonitroalkene ( I ) which was found to have antibacterial and antimicrobial properties. The electron transfer kinetic parameters such as the charge transfer coefficient α and heterogeneous rate constant k′ were calculated and they have been found to be 0.64 and 9.62 × 10 −2 cm s −1 respectively. The linear response ranges for ( I ) obtained at this sensor are 1.0 × 10 −7 M − 7.0 × 10 −7 M and 1.0 × 10 −6 M – 4.5 × 10 −5 M with a detection limit of (7.03 ± 0.41) × 10 −8 M (S/N=3). The interference study suggested that the sensor was free from 1000‐fold excess of UA in the determination of ( I ). It was important to note that the sensor completely eliminated Ascorbic acid (AA) signal which offered a significant analytical advantage for the determination of the drug at this sensor. The practical usefulness of the modified sensor was demonstrated by the analysis of ( I ) in blood serum.