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Analysis of Levodopa in the Presence of Vitamin B 6 Using Carbon Paste Electrode Modified with 1‐Butyl‐3 methylimidazolium Hexafluorophosphate and CuO Nanoparticles
Author(s) -
KarimiMaleh Hassan,
Shojaei Moein,
Amini Fatemeh,
Akbari Ahmad
Publication year - 2017
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201600785
Subject(s) - hexafluorophosphate , levodopa , ionic liquid , carbon paste electrode , nanoparticle , electrochemistry , materials science , electrode , nuclear chemistry , chemistry , nanotechnology , cyclic voltammetry , organic chemistry , catalysis , parkinson's disease , medicine , disease , pathology
A carbon paste electrode modified with 1‐butyl‐3‐methylimidazolium hexafluorophosphate ionic liquid (BMIPF6) and CuO nanoparticles (CuO/NPs) (CPE/BMIPF 6 /CuO/NPs) was fabricated and used for square wave voltammetric analysis of levodopa in the presence of vitamin B 6 . The elemental analysis, SEM and XRD methods were used for characterization of synthesized CuO nanoparticle. CPE/BMIPF 6 /CuO/NPs exhibited high electrical conductivity toward the electro‐oxidation of levodopa at a pH=7.0 as best experimental condition. Using CPE/BMIPF 6 /CuO/NPs the levodopa and vitamin B 6 peaks are separated and oxidized at potentials of 0.565 V and 0.835 V, respectively; hence levodopa can be detected in the presence of vitamin B 6 . The electrochemical response shows a linear relationship from concentration of levodopa and vitamin B 6 in the ranges of 0.06‐1000 μM and 0.1‐700.0 μM, respectively. Finally, CPE/BMIPF 6 /CuO/NPs were applied as high performance tool for determination of levodopa and vitamin B 6 in real samples.
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