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Cathodized Gold Nanoparticle‐Modified Graphite Pencil Electrode for Non‐Enzymatic Sensitive Voltammetric Detection of Glucose
Author(s) -
Kawde AbdelNasser,
Aziz Md. Abdul,
ElZohri Manal,
Baig Nadeem,
Odewunmi Nurudeen
Publication year - 2017
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201600709
Subject(s) - colloidal gold , ascorbic acid , fructose , detection limit , chemistry , sucrose , cyclic voltammetry , electrode , electrochemistry , nuclear chemistry , nanoparticle , biosensor , chromatography , inorganic chemistry , materials science , biochemistry , nanotechnology , food science
A highly sensitive enzymeless electrochemical glucose sensor has been developed based on the simply prepared cathodized gold nanoparticle‐modified graphite pencil electrode (AuNP‐GPE). Cyclic voltammetry (CV) experiments show that AuNP‐GPE is able to oxidize glucose partially at low potential (around −0.27) whereas the bare GPE cannot oxidize glucose in the entire tested potential windows. Besides, fructose and sucrose cannot be oxidized at potential lower than +0.1 V at AuNP‐GPE. As a result, the glucose oxidation peak at around −0.27 V is suitable enough for selective detection of glucose in the presence of fructose and sucrose. Cathodization of AuNP‐GPE under optimum condition (‐1.0 V for 30 s) in the same glucose solution before voltammetric measurement enhanced glucose oxidation peak current around −0.27 V to achieve an efficient electrochemical sensor for glucose with a detection limit of 12 μM and dynamic range between 0.05 to 5.0 mM with a good linearity (R 2 = 0.999). Almost no interference effect was observed for sensing of glucose in the presence of ascorbic acid, alanine, phenylalanine, fructose, sucrose, and NaCl.