Premium
Highly Selective Sensing Platform Utilizing Graphene Oxide and Multiwalled Carbon Nanotubes for the Sensitive Determination of Tramadol in the Presence of Co‐Formulated Drugs
Author(s) -
Mohamed Mona A.,
Atty Shimaa A.,
Salama Nahla N.,
Banks Craig E.
Publication year - 2017
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201600668
Subject(s) - chronoamperometry , graphene , cyclic voltammetry , materials science , differential pulse voltammetry , dielectric spectroscopy , electrochemical gas sensor , carbon nanotube , oxide , nuclear chemistry , analytical chemistry (journal) , electrochemistry , nanotechnology , chemistry , chromatography , electrode , metallurgy
Novel insights into the strategy of highly precise, carbon‐based electrochemical sensors are presented by exploring the excellent properties of graphene oxide (GO) and multiwalled carbon nanotube composites (GO‐MWCNTs/CPE) for the sensitive determination of tramadol hydrochloride (TRH). Cyclic voltammetry, differential pulse voltammetry, chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS) scanning electron microscopy, and X‐ray diffraction (XRD) techniques were used to characterize the properties of the sensor. The linear response obtained for TRH using the GO‐MWCNTs/CPE was found to be over the range of 2.0x10 −9 to 1.1x10 −3 M with a good linearity and high correlation (0.9996). The limits of detection and quantification were found to be 1.50x10 −10 M and 4.99 x 10 −10 M, respectively. The proposed sensor was applied for determination of TRH in the presence of presence of co‐formulated drugs ketorolac tromethamine (KTM) and paracetamol (PAR). The sensor was shown to successfully apply to the determination of TRH in plasma as real samples. Satisfactory recoveries of TRH from samples clearly revealed that the proposed sensor can be applied into clinical analysis, quality control and a routine determination of drugs in pharmaceutical formulations.