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Simultaneous Voltammetric Determination of Paracetamol, Codeine and Caffeine on Diamond‐like Carbon Porous Electrodes
Author(s) -
Silva Tiago Almeida,
Zanin Hudson,
Corat Evaldo José,
FatibelloFilho Orlando
Publication year - 2017
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201600665
Subject(s) - electrode , materials science , electrochemistry , detection limit , cyclic voltammetry , codeine , matrix (chemical analysis) , voltammetry , amperometry , carbon fibers , diamond , porosity , analytical chemistry (journal) , composite number , chromatography , chemistry , composite material , medicine , morphine , pharmacology
Abstract A porous electrode material combining the features of vertically aligned multi‐walled carbon nanotubes (VAMWCNT) and diamond‐like carbon films (DLC) have been developed for a highly sensitive electrochemical sensor. For working electrode preparation, DLC has been grown onto VAMWCNT, forming a porous, conductive and stable composite. The electrochemical performance of this DLC:VAMWCNT electrode has been investigated toward detection and analysis of three well‐known molecules, namely paracetamol, codeine and caffeine. A ternary mixture of these analytes was simultaneously determined under optimum experimental conditions using square‐wave voltammetry. Wide linear concentration ranges and the limits of detection of 3.34×10 −7 mol L −1 , 1.57×10 −7 mol L −1 and 3.67×10 −7 mol L −1 were obtained for paracetamol, codeine and caffeine, respectively. We conclude that the proposed voltammetric method and the DLC:VAMWCNT electrode comprise a reliable methodology for simultaneous determination of paracetamol, codeine and caffeine in biological matrix samples.