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Electrochemical Sensor Based on a Novel Pt−Au Bimetallic Nanoclusters Decorated on Reduced Graphene Oxide for Sensitive Detection of Ofloxacin
Author(s) -
Jiang Zhiming,
Liu Qin,
Tang Yuran,
Zhang Mingxiao
Publication year - 2017
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201600408
Subject(s) - graphene , ofloxacin , bimetallic strip , nanoclusters , materials science , fourier transform infrared spectroscopy , nanocomposite , oxide , detection limit , electrochemical gas sensor , electrochemistry , nuclear chemistry , scanning electron microscope , chemical engineering , nanotechnology , chemistry , metal , electrode , metallurgy , chromatography , composite material , biochemistry , engineering , ciprofloxacin , antibiotics
Abstract Pt−Au nanoclusters decorated on the surface of reduced graphene oxide (rGO/Pt−Au) was facilely prepared by one‐pot electrochemical reduction. The morphology and composition of rGO/Pt−Au composites had been characterized by scanning electron microscopy (SEM) coupled with energy‐dispersive X‐ray spectrometry (EDX), fourier transform‐infrared spectroscopy (FT‐IR) and electrochemical methods. Ofloxacin is a member of synthetic quinolones which has been widely used for the treatment of common diseases in humans and animals. The performance of the rGO/Pt−Au nanocomposite toward the oxidation of ofloxacin was compared with the other similar nanostructures like rGO/Pt and rGO/Au. In the optimized conditions, two linear calibration curves were obtained, from 0.08 to 10 μM and 10 to 100 μM ofloxacin. A detection limit of 0.05 μM ofloxacin was observed at pH 5.7 for the GCE/rGO/Pt−Au. The proposed sensor was successfully applied to determine ofloxacin in tablets and human urine samples and the results were satisfactory.