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A Novel Hybrid Nano‐composite Grafted Electrochemically Reduced Graphene Oxide Based Sensor for Sensitive Determination of Efavirenz
Author(s) -
Raj Mamta,
Gupta Pankaj,
Thapliyal Neeta,
Goyal Rajendra N.
Publication year - 2017
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201600397
Subject(s) - nafion , detection limit , materials science , graphene , pyrolytic carbon , dielectric spectroscopy , scanning electron microscope , linear range , oxide , graphite , electrochemical gas sensor , chemical engineering , electrochemistry , nanotechnology , analytical chemistry (journal) , chemistry , composite material , electrode , chromatography , pyrolysis , engineering , metallurgy
A novel, facile fabrication, based on electrochemically reduced graphene oxide (ErGO), grafted with Pt nanoparticles and Nafion hybrid nano‐composite (ErGO‐Pt/Nafion) on the surface of edge plane pyrolytic graphite (EPPG) has been reported. The fabricated sensor has been used for the sensitive and selective determination of efavirenz (EFZ), a well‐known drug for HIV infections. The ErGO‐Pt/Nafion film was characterized by Field Emission Scanning Electron Microscopy (FE‐SEM), Energy‐dispersive X‐ray spectrometry (EDS) and Electrochemical Impedance Spectroscopy (EIS). The experimental results reveal that the modified sensor displays an excellent electrocatalytic activity towards the oxidation of EFZ and exhibits a large linear dynamic relationship in the range of 0.05 μM to 150 μM, with a detection limit of 1.8 nM. Practical utility of the developed sensor has been demonstrated by determining the EFZ in biological fluids and pharmaceutical samples and a low detection limit with high sensitivity observed makes it valuable for the clinical diagnosis.