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Electrochemical Oxidation of the Antiretroviral Drug Nelfinavir on Modified Screen‐printed Electrodes
Author(s) -
AsturiasArribas Laura,
Delfino Mario Raúl,
AlonsoLomillo M. Asunción,
DomínguezRenedo Olga,
ArcosMartínez M. Julia
Publication year - 2016
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201600073
Subject(s) - nelfinavir , analyte , antiretroviral drug , electrochemistry , chromatography , electrode , carbon nanotube , materials science , chemistry , nanotechnology , human immunodeficiency virus (hiv) , antiretroviral therapy , medicine , viral load , family medicine
Abstract This paper describes the voltammetric study of the electrochemical oxidation of the antiretroviral drug Nelfinavir using a screen‐printed sensor modified with carbon nanotubes. The performance of the sensor in the determination of the drug was characterized in terms of precision (RSD 5.05 %, n =5) and capability of detection (10.99±0.87 μM for α = β =0.05, n =5) under optimized voltammetric conditions of pH, accumulation time and potential, in the calibration range from 10 to 150 μM of NFV. In order to check the viability of the device, the determination of the analyte in pharmaceutical and biological samples was carried out and its performance was also validated comparing it with HPLC.