Premium
An Electrochemical Sensing Strategy for Amantadine Detection Based on Competitive Host‐guest Interaction of Methylene Blue/β‐cyclodextrin/Poly(N‐acetylaniline) Modified Electrode
Author(s) -
Hao Xia,
Li Na,
Xu Zhen,
Li Nian Bing,
Luo Hong Qun
Publication year - 2016
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201501149
Subject(s) - methylene blue , electrochemistry , electrode , cyclodextrin , amantadine , molecule , host–guest chemistry , chemistry , organic chemistry , catalysis , supramolecular chemistry , photocatalysis , neuroscience , biology
A novel electrochemical strategy for the detection of amantadine (AMD) has been developed based on the competitive host‐guest interaction of AMD and methylene blue (MB) with β‐cyclodextrin (β‐CD). Due to the host‐guest interaction, MB molecules can enter into the hydrophobic inner cavity of β‐CD, and the MB/β‐CD/poly(N‐acetylaniline)/glassy carbon electrode displays a remarkable reduction peak due to MB. In the presence of AMD, competitive association to β‐CD occurs and the MB molecules are displaced by AMD, resulting in a decrease of reduction peak current of MB. The difference value of the cathodic peak current showed a linear relationship with the AMD concentration.