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Determination of Amlodipine and Atenolol by Batch Injection Analysis with Amperometric Detection on Boron‐doped Diamond Electrode
Author(s) -
Silva Almir A.,
Silva Luiz A. J.,
Munoz Rodrigo A. A.,
Oliveira Aline C.,
Richter Eduardo M.
Publication year - 2016
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201501138
Subject(s) - detection limit , amperometry , atenolol , chromatography , amlodipine , electrode , diamond , dilution , dissolution , electrolyte , analytical chemistry (journal) , materials science , chemistry , supporting electrolyte , medicine , metallurgy , electrochemistry , thermodynamics , physics , blood pressure , radiology
This work describes the sequential determination of amlodipine (AML) and atenolol (ATN) by batch injection analysis (BIA) with pulsed amperometric detection (BIA‐PAD). Boron doped diamond (BDD) was used as working electrode. AML was detected at +1.00 V and ATN at +1.65 V. The proposed BIA method is simple, robust, precise (RSD <3.2 %; n=10), presents high analytical frequency (>70 injections h −1 ), generates reduced volume of waste (without use of organic solvent) and requires minimal sample manipulation (dissolution and dilution in electrolyte). The limits of detection were 0.074 and 0.073 µmol L −1 for AML and ATN, respectively. The results obtained with the proposed BIA method were compared to those obtained by HPLC and similar results were obtained (at 95% of confidence level).