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Electrical Properties of HeLa Cells Based on Scalable 3D Interdigital Electrode Array
Author(s) -
Chang FuYu,
Chen MingKun,
Wang MinHaw,
Jang LingSheng
Publication year - 2016
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500624
Subject(s) - hela , electrode , materials science , substrate (aquarium) , scalability , electrical impedance , optoelectronics , equivalent circuit , phase (matter) , biomedical engineering , biological system , analytical chemistry (journal) , cell , computer science , chemistry , voltage , electrical engineering , chromatography , engineering , biology , ecology , biochemistry , organic chemistry , database
This study analyzed the electrical properties of a multiple‐cells using the electric cell‐substrate impedance sensing, a scalable three‐dimensional electrode array and an equivalent circuit model (ECM). The experimental results validated the accuracy and validity of the extraction method for the ECM. The ECM simulation results using the electrical properties extracted by measuring 52 HeLa cells successfully forecasted the impedance magnitudes and phases for 15, 29, 78, and 98 HeLa cells. Comparing the ECM simulations and measurements, the maximum average errors in magnitude and phase were 3.06 % and 4.67 %, suggesting the number of HeLa cells can be classified by their electrical properties.