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Determination of Ethambutol in Aqueous Medium Using an Inexpensive Gold Microelectrode Array as Amperometric Sensor
Author(s) -
Lima A. E. B.,
Luz G. E.,
Batista N. C.,
Longo E.,
Cavalcante L. S.,
Santos R. S.
Publication year - 2016
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500600
Subject(s) - detection limit , microelectrode , amperometry , ethambutol , chromatography , aqueous solution , chemistry , multielectrode array , standard curve , aqueous medium , analytical chemistry (journal) , electrochemistry , electrode , biochemistry , streptomycin , antibiotics
In this paper, gold microelectrode array (Au‐MEA) were employed to determination of ethambutol in aqueous medium. Au‐MEA was constructed with an electronic microchip integrated circuit. The standard curve (analytical curve) was constructed for a single microelectrode (ME) in a concentration range of 5.0×10 −5 to 2.0×10 −3 mol L −1 , allowing estimation of both the limit of detection (LOD) (4.73×10 −5 mol L −1 ) and the limit of quantification (LOQ) (1.57×10 −4 mol L −1 ) for ethambutol. When the MEA was utilized, the LOD and LOQ were 1.55×10 −7 and 5.18×10 −7 mol L −1 , respectively. Our results indicated that Au‐MEA can be utilized as amperometric sensors for ethambutol determination in aqueous media.