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Screening for Oral Cancer Using Electrochemical Telomerase Assay
Author(s) -
Hayakawa Mana,
Sato Shinobu,
Diala Irmina,
Kodama Masaaki,
TomoedaMori Kumiko,
Haraguchi Kazuya,
Tominaga Kazuhiro,
Takenaka Shigeori
Publication year - 2016
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500426
Subject(s) - telomerase , cancer , receiver operating characteristic , medicine , oral mucosa , volunteer , cancer research , gastroenterology , chemistry , pathology , biology , gene , biochemistry , agronomy
Electrochemical telomerase assay (ECTA) developed by our group was evaluated in an oral cancer screening using exfoliated oral cells and tissues obtained from patients of oral cancer, mucosa associated disease, or healthy volunteers. Telomerase activity from ECTA is correlated with hTERT mRNA expression level using a real‐time PCR and was increasing in the following order: healthy volunteer group