Premium
Batch‐injection versus Flow‐injection Analysis Using Screen‐printed Electrodes: Determination of Ciprofloxacin in Pharmaceutical Formulations
Author(s) -
Stefano Jéssica S.,
Cordeiro Denise S.,
Marra Mariana C.,
Richter Eduardo M.,
Munoz Rodrigo A. A.
Publication year - 2016
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500325
Subject(s) - amperometry , flow injection analysis , capillary electrophoresis , chromatography , linear range , ciprofloxacin , electrode , detection limit , chemistry , analytical chemistry (journal) , materials science , electrochemistry , biochemistry , antibiotics
This article highlights the potential use of multi‐walled carbon‐nanotube modified screen‐printed electrodes (SPEs) for the amperometric sensing of ciprofloxacin and compares the association of batch‐injection analysis (BIA) and flow‐injection analysis (FIA) with amperometric detection. Both analytical systems provided precise (RSD<5 %) and sensitive determination of ciprofloxacin (LOD<0.1 μmol L −1 ) within wide linear range (up to 200 μmol L −1 ). Accuracy of both methods was attested by recovery values (93–107 %) and comparison with capillary electrophoresis. The BIA system is completely portable (especially due to association with SPEs) and provided faster analyses (130 h −1 ) and more sensitive detection than the FIA system due to the higher flow rates of injection.