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Nanocellulose/Carbon Nanoparticles Nanocomposite Film Modified Electrode for Durable and Sensitive Electrochemical Determination of Metoclopramide
Author(s) -
Shahrokhian Saeed,
Naderi Leila,
Ghalkhani Masoumeh
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500266
Subject(s) - materials science , electrode , dielectric spectroscopy , nanocomposite , cyclic voltammetry , nanocellulose , electrochemistry , chemical engineering , nanoparticle , glassy carbon , scanning electron microscope , detection limit , analytical chemistry (journal) , nanotechnology , chemistry , cellulose , composite material , chromatography , engineering
A novel electrochemical sensor based on nanocellulose‐carbon nanoparticles (NC‐CNPs) nanocomposite film modified glassy carbon electrode (GCE) is developed for the analysis of metoclopramide (MCP). Atomic force microscopy, scanning electron microscopy and electrochemical impedance spectroscopy were used to characterize the roughness, surface morphology and performance of the deposited modifier film on GCE. SEM image demonstrated that modifier nanoparticles are uniformly deposited on GCE, with an average size of less than 50 nm. The electrochemical behavior of MCP and its oxidation product is studied using linear sweep and cyclic voltammetry over a wide pH range on NC‐CNPs modified glassy carbon electrode. The results revealed that the oxidation of MCP is an irreversible and pH‐dependent process that proceeds in an adsorption‐controlled mechanism and results in the formation of a main oxidation product, which adsorbs on the surface of NC‐CNPs/ GCE. The modified electrode showed a distinctive anodic response towards MCP with a considerable enhancement (49 fold) compared to the bare GCE. Under the optimized conditions, the modified electrode exhibited a wide linear dynamic range of 0.06–2.00 µM with a detection limit of 6 nM for the voltammetric determination of MCP. The prepared modified electrode showed several advantages such as simple preparation method, high stability, reproducibility, and repetitive usability. The modified electrode is successfully applied for the accurate determination of trace amounts of MCP in pharmaceutical and clinical preparations.