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Nanomolar Determination of Methyldopa in the Presence of Large Amounts of Hydrochlorothiazide Using a Carbon Paste Electrode Modified with Graphene Oxide Nanosheets and 3‐(4′‐Amino‐3′‐hydroxy‐biphenyl‐4‐yl)‐acrylic Acid
Author(s) -
Mohammadi Seyed Zia,
Beitollahi Hadi,
Jasemi Malihe,
Akbari Ali
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500245
Subject(s) - graphene , detection limit , hydrochlorothiazide , oxide , electrode , methyldopa , electrochemistry , chemistry , carbon paste electrode , biphenyl , cyclic voltammetry , inorganic chemistry , materials science , chromatography , organic chemistry , nanotechnology , medicine , blood pressure , radiology
A novel electrochemical sensor for sensitive detection of methyldopa at physiological pH was developed by the bulk modification of carbon paste electrode (CPE) with graphene oxide nanosheets and 3‐(4′‐amino‐3′‐hydroxy‐biphenyl‐4‐yl)‐acrylic acid (3,′AA). Applying square wave voltammetry (SWV), in phosphate buffer solution (PBS) of pH 7.0, the oxidation current increased linearly with two concentration intervals of methyldopa, one is 1.0×10 −8 –1.0×10 −6 M and the other is 1.0×10 −6 –4.5×10 −5 M. The detection limit (3 σ ) obtained by SWV was 9.0 nM. The modified electrode was successfully applied for simultaneous determination of methyldopa and hydrochlorothiazide. Finally, the proposed method was applied to the determination of methyldopa and hydrochlorothiazide in some real samples.