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An Electrochemical Sensor for the Simultaneous Determination of Paracetamol and Codeine Using a Glassy Carbon Electrode Modified with Nickel Oxide Nanoparticles and Carbon Black
Author(s) -
Batista Deroco Patrícia,
Campanhã Vicentini Fernando,
FatibelloFilho Orlando
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500156
Subject(s) - carbon black , glassy carbon , electrochemical gas sensor , nickel , electrochemistry , electrode , square wave , carbon fibers , nanoparticle , voltammetry , oxide , nickel oxide , carbon paste electrode , materials science , chemistry , inorganic chemistry , cyclic voltammetry , nanotechnology , organic chemistry , natural rubber , physics , quantum mechanics , voltage , composite material , composite number
In this work, a simple and highly selective voltammetric method was developed for the simultaneous determination of paracetamol (PCT) and codeine (COD) in pharmaceuticals and human body fluids employing a glassy carbon electrode modified with carbon black (CB) and nickel oxide nanoparticles (NiONPs) within a dihexadecylphosphate (DHP) film. Using square‐wave voltammetry (SWV), a separation of ca. 550 mV between the oxidation peak potentials of PCT and COD was obtained. The simultaneous determination of PCT and COD presented a linear concentration range from 3.0 to 47.8 µmol L −1 for PCT and from 0.83 to 38.3 µmol L −1 for COD.