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Direct Electrochemistry of Glucose Oxidase at Reduced Graphene Oxide and β‐Cyclodextrin Composite Modified Electrode and Application for Glucose Biosensing
Author(s) -
Palanisamy Selvakumar,
Devasenathipathy Rajkumar,
Chen ShenMing,
Ajmal Ali M.,
Karuppiah Chelladurai,
Balakumar V.,
Prakash P.,
Elshikh Mohamed S.,
AlHemaid Fahad M. A.
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500150
Subject(s) - glucose oxidase , biosensor , graphene , electrochemistry , redox , oxide , electron transfer , detection limit , cyclodextrin , electrode , chemistry , composite number , materials science , nuclear chemistry , chemical engineering , inorganic chemistry , nanotechnology , chromatography , organic chemistry , composite material , engineering
A simple glucose biosensor has been developed based on direct electrochemistry of glucose oxidase (GOx) immobilized on the reduced graphene oxide (RGO) and β‐cyclodextrin (CD) composite. A well‐defined redox couple of GOx appears with a formal potential of ∼−0.459 V at RGO/CD composite. A heterogeneous electron transfer rate constant ( K s ) has been calculated for GOx at RGO/CD as 3.8 s −1 . The fabricated biosensor displays a wide response to glucose in the linear concentrations range from 50 µM to 3.0 mM. The sensitivity and limit of detection of the biosensor is estimated as 59.74 µA mM −1 cm −2 and 12 µM, respectively.
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