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Enantioselective Recognition of DOPA by Mesoporous Platinum Imprinted with Mandelic Acid
Author(s) -
Yutthalekha Thittaya,
Warakulwit Chompunuch,
Limtrakul Jumras,
Kuhn Alexander
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500145
Subject(s) - mandelic acid , enantiomer , mesoporous material , platinum , enantioselective synthesis , chemistry , combinatorial chemistry , catalysis , organic chemistry
Chiral imprinted mesoporous platinum was electrochemically synthesized in the presence of mandelic acid and Brij 56 surfactant as chiral and mesoporous templates, respectively. The chiral cavity obtained by using mandelic acid as a template can be used to distinguish between enantiomers of other chiral molecules in which the stereocentre has a correlated configuration with respect to the imprinted one. This recognition versatility was tested for the discrimination of DOPA enantiomers. Mesoporous platinum electrodes imprinted with ( R )‐mandelic acid preferentially react with L ‐DOPA and vice versa for the ( S )‐mandelic acid imprinted one, which is more reactive for D ‐DOPA.