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Electroanalysis of Natural Compounds as Copper Chelating Agents for Alzheimer’s Disease Therapy
Author(s) -
Hung Vinci Wing Sze,
Bressan Lucas Paines,
Seo Kanghoon,
Kerman Kagan
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500138
Subject(s) - clioquinol , baicalein , chelation , chemistry , chelation therapy , differential pulse voltammetry , copper , resveratrol , pharmacology , nuclear chemistry , cyclic voltammetry , electrochemistry , biochemistry , inorganic chemistry , medicine , organic chemistry , electrode
The development of therapeutic compounds that can attenuate the toxicity exerted by the accumulation of metal ions has been an area of intensive research in neurodegenerative diseases. In this report, an electrochemical method was developed to determine the Cu(II)‐chelating ability of polyphenols that were implicated in Alzheimer’s disease (AD). The results suggested the strength of flavonoids to chelate Cu(II) as epigallocatechin‐3‐gallate (EGCG)>resveratrol>clioquinol>baicalein∼ scyllo ‐inositol. Furthermore, the number of hydroxyl groups was found to play a role to lower Cu(II) oxidation signal using differential pulse voltammetry.