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Multiwalled Carbon Nanotubes‐Chitosan Modified Single‐Use Biosensors for Electrochemical Monitoring of Drug‐DNA Interactions
Author(s) -
Sengiz Ceren,
Congur Gulsah,
Eksin Ece,
Erdem Arzum
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500107
Subject(s) - cyclic voltammetry , differential pulse voltammetry , chitosan , carbon nanotube , electrochemistry , dielectric spectroscopy , biosensor , guanine , nuclear chemistry , chemistry , electrode , voltammetry , electrochemical gas sensor , chemical engineering , materials science , analytical chemistry (journal) , nanotechnology , chromatography , organic chemistry , biochemistry , nucleotide , engineering , gene
A multiwalled carbon nanotubes (CNT)‐chitosan (CHIT) modified pencil graphite electrode (CNT‐CHIT/PGE) was developed for the first time herein for electrochemical monitoring of the interaction of an anticancer drug, mitomycin C (MC) and DNA. The characterization of unmodified PGE, CHIT/PGE, CNT/PGE and CHIT‐CNT/PGE were performed by scanning electron microscopy and cyclic voltammetry techniques. The oxidation signals of MC and guanine were measured before and after interaction at the surface of CNT‐CHIT/PGEs using differential pulse voltammetry. Electrochemical impedance spectroscopy technique was also successfully utilized for monitoring of the interaction process at the surface of CNT‐CHIT/PGEs in different interaction times.