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Electrografting of 4‐ tert ‐Butylcatechol on GC Electrode. Selective Electrochemical Determination of Homocysteine
Author(s) -
Salehzadeh Hamid,
Nematollahi Davood,
Alizadeh Saber
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500091
Subject(s) - electrode , detection limit , electrochemistry , glassy carbon , redox , chemistry , homocysteine , linear range , electrochemical gas sensor , working electrode , inorganic chemistry , analytical chemistry (journal) , cyclic voltammetry , chromatography , biochemistry
A new sensor based on the grafting of 4‐ tert ‐butylcatechol on the surface of a glassy carbon electrode (GC) was developed for the catalytic oxidation of homocysteine ( Hcy ). The GC‐modified electrode exhibited a reversible redox response at neutral pH. Under the optimum conditions cyclic voltammetric results indicated the excellent electrocatalytic activity of modified electrode toward the oxidation of Hcy at reduced over‐potential about 350 mV. A linear dynamic range of 0.01–3.0 mM and a detection limit of 1.0 µM were obtained for Hcy . The modified electrode was used as an electrochemical sensor for selective determination of Hcy in human blood.