Premium
Electrochemical Detection of Interaction Between α‐Synuclein and Clioquinol
Author(s) -
Cheng Xin R.,
Kerman Kagan
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201500044
Subject(s) - clioquinol , thioflavin , chemistry , electrochemistry , congo red , pathogenesis , biophysics , fluorescence , pharmacology , combinatorial chemistry , alzheimer's disease , disease , medicine , biology , electrode , organic chemistry , adsorption , quantum mechanics , physics
α‐Synuclein (α‐S) protein is expressed in presynaptic terminals in the central nervous system. The aggregation of α‐S is implicated in the pathogenesis of Parkinson’s disease (PD). In this report, the interaction of α‐S with clioquinol (CQ) was investigated in the presence of Cu(II) ions using electrochemistry, as well as Thioflavin T‐based fluorescence and Congo Red‐based UV‐Vis studies. In the presence of CQ, the α‐S aggregation rate was observed to decrease. The preliminary results showed promise in the future development of CQ derivatives as novel small molecule therapeutic agents with potential efficacy targeting α‐S in PD therapy.