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A pH Responsive Redox Hydrogel for Electrochemical Detection of Redox Silent Biocatalytic Processes. Control of Hydrogel Solvation
Author(s) -
Contin Andrea,
Frasca Stefano,
Vivekananthan Jeevanthi,
Leimkühler Silke,
Wollenberger Ulla,
Plumeré Nicolas,
Schuhmann Wolfgang
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400621
Subject(s) - redox , chemistry , solvation , electron transfer , imidazole , electrochemistry , protonation , half reaction , self healing hydrogels , combinatorial chemistry , photochemistry , polymer chemistry , inorganic chemistry , organic chemistry , solvent , electrode , ion
The control of bioelectrocatalytic processes by external stimuli for the indirect detection of non‐redox active species was achieved using an esterase and a redox enzyme both integrated within a redox hydrogel. The poly(vinyl)imidazole Os(bpy) 2 Cl hydrogel displays pH‐responsive properties. The esterase catalysed reaction leads to a local pH decrease causing protonation of imidazole moieties thus increasing hydrogel solvation and mobility of the tethered Os‐complexes. This is the key step to enable improved electron transfer between an aldehyde oxidoreductase and the polymer‐bound Os‐complexes. The off‐on switch is further integrated in a biofuel cell system for self‐powered signal generation.