Impedimetric DNA‐Based Biosensor for Silver Ions Detection with Hemin/G‐Quadruplex Nanowire as Enhancer | Zendy

Liu Guangpeng | Zendy; Yuan Yali | Zendy; Wei Shiqiang | Zendy; Zhang Dujian | Zendy

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Impedimetric DNA‐Based Biosensor for Silver Ions Detection with Hemin/G‐Quadruplex Nanowire as Enhancer

Author(s) -

Liu Guangpeng,

Yuan Yali,

Wei Shiqiang,

Zhang Dujian

Publication year - 2014

Publication title -

electroanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 128

eISSN - 1521-4109

pISSN - 1040-0397

DOI - 10.1002/elan.201400439

Subject(s) - hemin , biosensor , detection limit , dielectric spectroscopy , g quadruplex , chemistry , dna , aptamer , cytosine , deoxyribozyme , ion , electrochemistry , materials science , electrode , microbiology and biotechnology , heme , biochemistry , chromatography , enzyme , biology , organic chemistry

A DNA‐based biosensor was reported for detection of silver ions (Ag + ) by electrochemical impedance spectroscopy (EIS) with [Fe(CN) 6 ] 4−/3− as redox probe and hybridization chain reaction (HCR) induced hemin/G‐quadruplex nanowire as enhanced label. In the present of target Ag + , Ag + interacted with cytosine‐cytosine (CC) mismatch to form the stable CAg + C complex with the aim of immobilizing the primer DNA on electrode, which thus triggered the HCR to form inert hemin/G‐quadruplex nanowire with an amplified EIS signal. As a result, the DNA biosensor showed a high sensitivity with the concentration range spanning from 0.1 nM to 100 µM and a detection limit of 0.05 nM.

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