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Amperometric In Vitro Monitoring of Penetration through Skin Membrane
Author(s) -
Gari Hala,
Rembiesa Jadwiga,
Masilionis Ignas,
Vreva Naida,
Svensson Birgitta,
Sund Torbjörn,
Hansson Henri,
Morén Anna Karin,
Sjöö Malin,
Wahlgren Marie,
Engblom Johan,
Ruzgas Tautgirdas
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400426
Subject(s) - penetration (warfare) , ascorbic acid , membrane , amperometry , electrode , hydrogen peroxide , chemistry , chromatography , organic chemistry , electrochemistry , biochemistry , food science , operations research , engineering
The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharmaceutical creams. From real‐time measurements of electrode current, fluxes and diffusion coefficients of mentioned compounds in skin membranes have been estimated.