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Voltammetric Determination of Nitrofurantoin at a Mercury Meniscus Modified Silver Solid Amalgam Electrode
Author(s) -
Krejčová Zuzana,
Barek Jiří,
Vyskočil Vlastimil
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400410
Subject(s) - differential pulse voltammetry , chemistry , voltammetry , amalgam (chemistry) , detection limit , cyclic voltammetry , analytical chemistry (journal) , mercury (programming language) , electrochemistry , nuclear chemistry , electrode , chromatography , computer science , programming language
Electrochemical behavior of nitrofurantoin (NF) was studied by direct current voltammetry (DCV), differential pulse voltammetry (DPV), and cyclic voltammetry (CV) using a mercury meniscus modified silver solid amalgam electrode (m‐AgSAE). Voltammetric behavior of NF was studied in cathodic region of potentials in dependence on pH. pH 7.0 was selected as an optimal medium for the determination of NF by both DCV and DPV, with the optimal methanolwater volume ratio of 1 : 9. In order to reduce the negative influence of electrode passivation, the suitable regeneration potentials were found (0 mV and −900 mV). The optimal conditions were found for the determination of NF in concentration ranges from 6×10 −6 mol L −1 to 1×10 −4 mol L −1 using DCV technique, and from 2×10 −7 mol L −1 to 1×10 −4 mol L −1 using DPV technique, both in the medium of methanolBritton–Robinson buffer pH 7.0 (1 : 9). The attained limit of quantification ( LOQ ) of NF was 1.6×10 −6 mol L −1 for DCV and 8.1×10 −8 mol L −1 for DPV. The practical applicability of the newly developed DPV method was verified by direct determination of NF in model samples of drinking and river water, with LOQ s 2.2×10 −7 mol L −1 and 2.5×10 −7 mol L −1 , respectively.