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Electroanalytical Sensor Based on Unmodified Screen‐Printed Carbon Electrode for the Determination of Levo‐Thyroxine
Author(s) -
Das Ashis,
Sangaranarayanan M. V.
Publication year - 2015
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400395
Subject(s) - chronoamperometry , differential pulse voltammetry , detection limit , phosphate buffered saline , electrode , electrochemistry , carbon paste electrode , chemistry , cyclic voltammetry , buffer solution , analytical chemistry (journal) , electroanalytical method , materials science , chromatography , potentiometric titration
The electrochemical behaviour of thyroxine (T 4 ) is analysed using the disposable screen‐printed carbon electrode (SPCE) in the neutral phosphate buffer solution with cyclic voltammetric technique. The Differential Pulse Voltammetry and Chronoamperometry were employed for sensing of T 4 . The lowest detection limit of 3 nM was obtained from the differential pulse voltammetric method without preconditioning. The Density Functional Theoretical study of T 4 was performed to elucidate the mechanism of oxidation. The analysis of the commercial pharmaceutical samples indicates the validity of the proposed method.