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Interference‐Free Electrochemical Detection of Nanomolar Dopamine Using Doped Polypyrrole and Silver Nanoparticles
Author(s) -
Saha Suparna,
Sarkar Priyabrata,
Turner Anthony P. F.
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400332
Subject(s) - polypyrrole , ascorbic acid , differential pulse voltammetry , detection limit , dielectric spectroscopy , cyclic voltammetry , amperometry , materials science , sulfonic acid , electrochemistry , linear range , nuclear chemistry , analytical chemistry (journal) , chemistry , chromatography , electrode , polymer chemistry , food science
Abstract This paper presents a new approach to detect dopamine in nanomolar range using an electrochemical sensor utilizing a composite made of chitosan‐stabilized silver nanoparticles and p ‐toluene sulfonic acid‐doped ultrathin polypyrrole film. Studies included cyclic voltammogram, amperometry, differential pulse voltammetry and also investigation by electrochemical impedance spectroscopy. A detection limit of 0.58 nM was achieved in the linear range 1×10 −9 M to 1.2×10 −7 M. High sensitivity towards DA, good reproducibility and long‐term stability have been demonstrated without interference from ascorbic acid, uric acid, epinephrine, L ‐dopa, glucose. The sensing system was successfully applied for quantitative determination of dopamine in commercially available human blood serum.