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Development of a Simple and Fast Electrochemical Method for Screening and Stoichiometric Determination of Dimenhydrinate
Author(s) -
Machado Freitas Jhonys,
da Costa Oliveira Thiago,
Silva Polyana Luiza,
Tofanello Gimenes Denise,
Abarza Munoz Rodrigo Alejandro,
Richter Eduardo Mathias
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400300
Subject(s) - stoichiometry , chemistry , amperometry , chromatography , electrochemistry , calibration curve , dosage form , analytical chemistry (journal) , detection limit , materials science , electrode
Dimenhydrinate (DIM) is a salt composed by the combination of two active pharmaceutical ingredients: diphenhydramine (DIP) and 8‐chlorotheophylline (CTP). In this work, the use of batch injection analysis with multiple pulse amperometric detection (BIA‐MPA) was proposed for the first time for fast stoichiometric determination of DIM. DIP (cation) and CTP (anion) were determined simultaneously in pharmaceutical samples with a simple and fast injection procedure (70 injections h −1 ). Additional strategies were also proposed for rapid screening of samples containing the DIM salt. By a simple injection of a sample into the BIA system (without using of calibration curve), reliable information about stoichiometry of the DIM salt (1 : 1; DIP:CTP) and presence or absence of interfering species (electroactive) can be achieved.