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A High Sensitivity Electrochemical Sensor Based on Fe 3+ ‐Ion Molecularly Imprinted Film for the Detection of T‐2 Toxin
Author(s) -
Gao Xing,
Cao Wenying,
Chen Miaomiao,
Xiong Huayu,
Zhang Xiuhua,
Wang Shengfu
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400237
Subject(s) - chelation , metal ions in aqueous solution , molecularly imprinted polymer , selectivity , electrochemistry , template , materials science , detection limit , ion , nuclear chemistry , metal , combinatorial chemistry , chemistry , nanotechnology , chromatography , inorganic chemistry , electrode , organic chemistry , metallurgy , catalysis
The excellent detection sensitivity in various matrices of T‐2 toxin (T‐2), which has cytotoxic and immunosuppressive effects in DNA and RNA synthesis, is a highly desirable characteristic. A sensitive molecularly imprinted electrochemical sensor was constructed for the selective detection of T‐2. In this study, iron ions (Fe 3+ ) were introduced to increase the chelation of the metal ions and templates for preparing molecularly imprinted polymers (MIPs). With the increased chelation of the metal ions and templates, the selectivity and sensitivity of the MIPs were effectively improved. The imprinted sensor was successfully employed to detect T‐2 in cereals and human serum samples.