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Electrosensing Platform for Varenicline Based on Reduced Graphene Oxide
Author(s) -
Teradal Nagappa L.,
Narayan Prashanth S,
Seetharamappa Jaldappagari,
Satpati Ashis K.
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400226
Subject(s) - graphene , oxide , materials science , raman spectroscopy , electrochemistry , varenicline , fourier transform infrared spectroscopy , detection limit , electrochemical gas sensor , chemical engineering , nuclear chemistry , nanotechnology , chemistry , electrode , chromatography , physics , engineering , neuroscience , optics , metallurgy , nicotine , biology
Graphene oxide (GO) was synthesized and reduced by chemical, hydrothermal and electrochemical methods. The GO and reduced GO was characterized by XRD, FTIR, absorption, Raman, FESEM and AFM methods. Chemically reduced GO (CrGO) was observed to efficiently enhance the electron transfer kinetics of varenicline compared to hydrothermally and electrochemically reduced GO. Hence, CrGO was used for the fabrication of an electrochemical sensor for the determination of varenicline in the concentration range of 0.03–50 µM with a limit of detection of 7.03 nM. The applicability of the proposed sensor was demonstrated by analyzing the biological samples containing varenicline.