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Nanostructured Base Electrochemical Sensor for Simultaneous Quantification and Voltammetric Studies of Levodopa and Carbidopa in Pharmaceutical Products and Biological Samples
Author(s) -
Beitollahi Hadi,
Mostafavi Mortaza
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400074
Subject(s) - charge transfer coefficient , cyclic voltammetry , detection limit , electrode , electrochemistry , horizontal scan rate , carbidopa , redox , voltammetry , chemistry , carbon paste electrode , analytical chemistry (journal) , materials science , inorganic chemistry , chromatography , levodopa , medicine , disease , pathology , parkinson's disease
A novel carbon paste electrode modified with carbon nanotubes and 5‐amino‐2′‐ethyl‐biphenyl‐2‐ol (5AEB) was fabricated. The electrochemical study of the modified electrode, as well as its efficiency for electrocatalytic oxidation of levodopa (LD) and carbidopa (CD), is described. Cyclic voltammetry (CV) was used to investigate the redox properties of this modified electrode at various scan rates. The apparent charge transfer rate constant, k s , and transfer coefficient, a , for electron transfer between 5AEB and CPE were calculated as 17.3 s −1 and 0.5, respectively. Square wave voltammetry (SWV) exhibits a linear dynamic range from 2.5×10 −7 to 2.0×10 −4 M and a detection limit of 9.0×10 −8 M for LD.