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Label‐Free Sensing of Biomolecules with Field‐Effect Devices for Clinical Applications
Author(s) -
Poghossian Arshak,
Schöning Michael J.
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400073
Subject(s) - biomolecule , nanotechnology , personalized medicine , biosensor , computer science , computational biology , materials science , bioinformatics , biology
Abstract Among the variety of transducer concepts proposed for label‐free detection of biomolecules, the semiconductor field‐effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label‐free, fast and real‐time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point‐of‐care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label‐free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody‐antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.