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Performance Improvement by Layout Designs of Conductive Polymer Microelectrode Based Impedimetric Biosensors
Author(s) -
Rosati Giulio,
Daprà Johannes,
Cherré Solène,
Rozlosnik Noemi
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400062
Subject(s) - microelectrode , biosensor , dielectric spectroscopy , materials science , microfluidics , electrode , multielectrode array , pedot:pss , conductive polymer , nanotechnology , polymer , microsystem , electrochemistry , electrical impedance , chemistry , composite material , electrical engineering , engineering
In this work we present a theoretical, computational, and experimental evaluation of the performance of an impedimetric biosensor based on interdigitated conductive polymer (PEDOT:TsO) microelectrodes in a microfluidic system. The influence of the geometry of the electrodes and microchannels on the electrochemical performance of the biosensor was exploited to improve the detection system. The developed model allowed us to predict the performance of the electrochemical system, and thus to optimize the geometry for electrochemical impedance spectroscopy (EIS). Finally, the optimized electrode design was validated by the detection of a clinically relevant target (ampicillin) at picomolar concentrations.