Premium
Electrochemical Detection of miRNAs
Author(s) -
Lautner Gergely,
Gyurcsányi Róbert E.
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400055
Subject(s) - microrna , nanotechnology , electrochemistry , computer science , detection limit , perspective (graphical) , computational biology , materials science , chemistry , biology , chromatography , artificial intelligence , electrode , biochemistry , gene
The recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. The progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and nanostructures. These enable a rigorous control over the sensing interface, provide enormous signal amplifications and single‐base mismatch specificity. Femtomolar or even subfemtomolar detection limits were shown to be feasible by electrochemical assays. Thus electrochemical detection methodologies are of perspective for diagnostic miRNA detection.