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Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode
Author(s) -
Mladenović Aleksandar R.,
Mijin Dušan Ž.,
Drmanić Saša Ž.,
Vajs Vlatka E.,
Jovanović Vladislava M.,
Petrović Slobodan D.,
Ivić Milka L. Avramov
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400034
Subject(s) - donepezil , cyclic voltammetry , voltammetry , electrochemistry , chemistry , electrode , medicine , dementia , disease , pathology
The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer’s disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.