Premium
A Novel Potentiometric Detection Strategy for the Determination of Amlodipine Besylate Based on Functionalized Particles
Author(s) -
ElKosasy Amira M.,
Tawakkol Shereen M.,
Ayad Miriam F.,
Sheta Ahmed I.
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201400025
Subject(s) - ionophore , potentiometric titration , potentiometric sensor , amlodipine , membrane , analyte , nanoparticle , plasticizer , chemical engineering , materials science , chemistry , ion , combinatorial chemistry , nanotechnology , chromatography , organic chemistry , medicine , biochemistry , blood pressure , engineering , radiology
A novel potentiometric strategy based on functionalized magnetite nanoparticles and microparticles were compared with the classical potentiometric strategy. This strategy provided nano‐ and microsized particles that were highly dispersed and coated with ionophore and plasticizer to promote an in situ cooperative ion‐pairing interaction between the ionophore and the analyte present in inner solution of sensor membrane, compared to the classical technique. Three amlodipine (AML) sensors were constructed using functionalized nanoparticles in sensor 1; microparticles in sensor 2, as ionophores, and the polymeric membrane ionophoric property in sensor 3.