Premium
First Report for Electrochemical Determination of Levodopa and Cabergoline: Application for Determination of Levodopa and Cabergoline in Human Serum, Urine and Pharmaceutical Formulations
Author(s) -
Tajik Somayeh,
Taher Mohammad Ali,
Beitollahi Hadi
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201300589
Subject(s) - cabergoline , levodopa , electrode , electrochemistry , chemistry , ionic liquid , carbon paste electrode , urine , organic chemistry , cyclic voltammetry , parkinson's disease , catalysis , medicine , biochemistry , disease , hormone , prolactin
Abstract The electrochemical oxidation of levodopa on the surface of a carbon paste electrode modified with graphene nanosheets, 1‐(4‐bromobenzyl)‐4‐ferrocenyl‐1 H ‐[1,2,3]‐triazole (1,4‐BBFT) and hydrophilic ionic liquid ( n ‐hexyl‐3‐methylimidazolium hexafluoro phosphate) as a binder is studied. It has been found that the oxidation of levodopa at the surface of a modified electrode occurs at a potential of about 210 mV less positive than that of an unmodified carbon paste electrode (CPE). The prepared modified electrode exhibits a very good resolution of the voltammetric peaks of levodopa and cabergoline. The electrode has been applied successfully for the determination of levodopa and cabergoline in some real samples.