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Adsorptive Stripping Voltammetric Determination of Imipramine and Amitriptiline at a Nanoclay Composite Carbon Ionic Liquid Electrode
Author(s) -
Eslami E.,
Farjami F.,
Aberoomand Azar P.,
Saber Tehrani M.
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201300557
Subject(s) - electrode , ionic liquid , nanocomposite , montmorillonite , stripping (fiber) , carbon paste electrode , materials science , electrochemistry , carbon fibers , composite number , detection limit , chemical engineering , imipramine , inorganic chemistry , chemistry , chromatography , cyclic voltammetry , nanotechnology , organic chemistry , composite material , catalysis , medicine , alternative medicine , pathology , engineering
Abstract A new carbon nanocomposite electrode has been designed by incorporation of montmorillonite nanoclay into a carbon ionic liquid electrode for the electrochemical determination of imipramine (IMP) and amitriptyline (AMT). They are expected to accumulate on the electrode surface through the cooperative interaction of ionic liquid and clay with the drugs. The proposed electrode also possesses attractive electrocatalytic effects towards the drugs especially AMT. Low detection limits of 19 nM for IMP and 24 nM for AMT were achieved. The proposed nanocomposite electrode exhibits good applicability for monitoring IMP and AMT in pharmaceutical formulations and blood serum samples.