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Application of PEDOT‐CNT Microelectrodes for Neurotransmitter Sensing
Author(s) -
Samba Ramona,
Fuchsberger Kai,
Matiychyn Ilona,
Epple Sebastian,
Kiesel Lydia,
Stett Alfred,
Schuhmann Wolfgang,
Stelzle Martin
Publication year - 2014
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201300547
Subject(s) - microelectrode , pedot:pss , ascorbic acid , dopamine , cyclic voltammetry , electrode , materials science , carbon nanotube , electrochemistry , poly(3,4 ethylenedioxythiophene) , chemistry , nanotechnology , medicine , food science
In this work, composite microelectrodes from poly(3,4‐ethylenedioxythiophene) (PEDOT) and carbon nanotubes (CNT) are characterized as electrochemical sensing material for neurotransmitters. Dopamine can be detected using square wave voltammetry at these microelectrodes. The CNTs improve the sensitivity by a factor of two. In addition, the selectivity towards dopamine in the presence of ascorbic acid and uric acid was examined. While both electrodes, PEDOT and PEDOT‐CNT are able to detect all measured concentrations of dopamine in the presence of uric acid, small concentrations of dopamine and ascorbic acid are only distinguishable at PEDOT‐CNT electrodes. Changing the pH has a strong influence on the selectivity. Moreover, it is possible to detect concentrations as low as 1 µM dopamine in complex cell culture medium. Finally, other catecholamines like serotonin, epinephrine, norepinephrine and L ‐dopa are also electrochemically detectable at PEDOT‐CNT microelectrodes.